Cardiac Muscle Cell Damage Through Autoimmune Mechanism. Can cardiac proteins provoke autoimmune myocarditis?
نویسندگان
چکیده
منابع مشابه
Nasal administration of cardiac myosin suppresses autoimmune myocarditis in mice.
OBJECTIVES This study was designed to examine whether myocarditis induced in a mouse model can be effectively suppressed by nasal administration of cardiac myosin (CM). BACKGROUND Myocarditis in humans often follows viral infection and is accompanied by evidence of an autoimmune response to CM. Treatment has been hampered by the fact that measures undertaken to reduce the autoimmune response ...
متن کاملMononuclear cell secretome in autoimmune myocarditis.
Myocarditis is defined as inflammation of cardiac muscle with or without myocyte necrosis. Both infectious and non-infectious aetiologies for myocarditis are known, but the most common is virus-induced myocarditis often followed by post-infectious inflammatory cardiomyopathy. Many RNA (picorna-, orthomyxo-, paramyxo-, and flaviviruses) as well as DNA (adeno-, erythro-, herpes-, and retroviruses...
متن کاملCaptopril prevents experimental autoimmune myocarditis.
Captopril, an angiotensin-converting enzyme inhibitor, is widely used in the treatment of a variety of cardiomyopathies, but its effect on autoimmune myocarditis has not been addressed experimentally. We investigated the effect of captopril on myosin-induced experimental autoimmune myocarditis. A/J mice, immunized with syngeneic cardiac myosin, were given 75 mg/L of captopril in their drinking ...
متن کاملResveratrol ameliorates experimental autoimmune myocarditis.
BACKGROUND Myosin-induced autoimmune myocarditis of rats is a model of human dilated cardiomyopathy. Resveratrol is a natural polyphenol found in grapes and wine that is reported to have cardioprotective and immunomodulatory effects. METHODS AND RESULTS To examine the effect of resveratrol on myocarditis, vehicle or resveratrol (50 mg/kg per day) was administered to cardiac myosin immunized r...
متن کاملIdentification of cardiac myosin peptides capable of inducing autoimmune myocarditis in BALB/c mice.
Immunization with cardiac myosin induces T cell-mediated myocarditis in genetically predisposed mice and serves as a model for autoimmune heart disease. This study was undertaken to identify pathogenic epitopes on the myosin molecule. Our approach was based on the comparison of the pathogenicity between cardiac (alpha-)myosin and soleus muscle (beta-)myosin. We show that alpha-myosin is the imm...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Japanese Circulation Journal
سال: 1991
ISSN: 0047-1828,1347-4839
DOI: 10.1253/jcj.55.1138